3'-Chloroacetophenone

3'-Chloroacetophenone can be used as a raw material for pharmaceutical synthesis, mainly for the synthesis of carbamazepine, a drug for the treatment of epilepsy, and as an intermediate for fine chemicals, pesticides, etc.

clear colourless to yellow liquid

3’-Chloroacetophenone is usd in the synthesis of GABA-AT inhibitors. Also used in the synthesis of antimycobacterial studies.

The Journal of Organic Chemistry, 60, p. 2361, 1995 DOI: 10.1021/jo00113a013

The activity of strain, Saccharomyces cerevisiae B5, on the reduction of 3′-chloroacetophenone was studied.

The first step of the reaction is to use anhydrous ether as solvent, carbon tetrachloride as initiating catalyst, from magnesium, anhydrous ethanol and diethyl malonate, at atmospheric pressure and 20 ~ 35 , heating reflux for 2 ~ 4 hours, while the preparation of magnesium ethoxymalonate malonate diethyl ester, the conversion rate of diethyl malonate can reach 85% to 90%; the second step of the reaction is to use anhydrous ether as solvent, at atmospheric pressure and temperature 30 ~ 35 , and The second step reaction is to use anhydrous ether as solvent, at atmospheric pressure and temperature 30 ~ 35 , by the magnesium ethoxide malonate and m-chlorobenzoyl malonate reaction to generate m-chlorobenzoyl malonate, m-chlorobenzoyl conversion rate of 90%, the selectivity of up to 85%; the third step reaction is in the aqueous sulfuric acid solution, under atmospheric pressure and temperature of 90 ~ 110 , heated reflux for 3-5 hours by the hydrolysis and decarboxylation of m-chlorobenzoyl malonate and m-chlorophenyl acetophenone generation, hydrolysis and decarboxylation rate of almost 100%. The hydrolysis and decarboxylation rate was almost 100%. After hydrolysis and decarboxylation, the reaction mixture is separated by distillation, and m-chloroacetophenone with content 99% can be obtained, and the yield of the product can be up to 75%85%.