基本属性 生物活性靶点体外研究体内研究 用途与合成方法 MSDS 盐酸氯吡胺 价格(试剂级) 上下游产品信息 供应商 供应信息 相关产品
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盐酸氯吡胺

盐酸氯吡胺

中文名称:盐酸氯吡胺
英文名称:Chloropyramine hydrochloride
CAS号:6170-42-9
分子式:C16H21Cl2N3
分子量:326.26
EINECS号:228-216-2
Mol文件:6170-42-9.mol
盐酸氯吡胺 结构式

盐酸氯吡胺 性质

熔点 172-174°
储存条件 Inert atmosphere,Room Temperature
溶解度 氯仿(微溶)、甲醇(微溶)、水(微溶)
颜色 白色至类白色
CAS 数据库 6170-42-9(CAS DataBase Reference)

盐酸氯吡胺 用途与合成方法

Chloropyramine hydrochloride 是一种组胺受体 H1 (histamine receptor H1) 拮抗剂,它也能抑制 VEGFR-3 和 FAK 的生化功能。

VEGFR-3

BT474 cells are highly sensitive to Chloropyramine hydrochloride (compound 1) treatment, whereby 1 µM concentrations cause a 40% reduction of viability after 48 h of treatment. It is found that at 1 µM concentrations of Chloropyramine hydrochloride, viability of control MCF7-pcDNA3 cells is significantly higher than the viability of MCF7-VEGFR-3 cells (P<0.01) and at 10 µM concentration this difference reaches twofold (P<0.001). In the BT474 cells treatment with Chloropyramine hydrochloride also leads to a concentration-dependent decrease of cell proliferation. When treatment with Chloropyramine hydrochloride is continued for 48 h, the breast cancer cells that overexpressed VEGFR-3 undergo apoptosis. This effect is dose-dependent, with 10 µM Chloropyramine hydrochloride inducing apoptosis in more than 60% of BT474 cells. In our model cell lines MCF7-pcDNA3 and MCF7-VEGFR-3, treatment with 10 µM Chloropyramine hydrochloride for 48 h leads to a 4-fold increase in apoptotic cell death in the cell line that overexpressed VEGFR-3 (18% versus 76 % respectively).

Chloropyramine hydrochloride causes a dramatic reduction of tumor growth in both model systems whereby the tumor size in the treated groups is approximately 20% of the tumor size in vehicle control groups. Doxorubicin administered at 3 mg/kg causes approximately 60% reduction of tumor growth, but has no effect on tumor growth at 0, 3 mg/kg. In contrast, there is a modest effect of Chloropyramine hydrochloride alone (50% reduction of tumor growth). The low-dose combination of Chloropyramine hydrochloride and doxorubicin has a prolonged anti-tumor effect (85% reduction of tumor growth) that is greater than either drug alone.

化学性质 
类白色至白色结晶性粉末。熔点168-172℃。
用途 
抗过敏药。
用途 
抗过敏原料药

安全信息

WGK Germany3

MSDS信息

语言:English
提供商:SigmaAldrich

盐酸氯吡胺 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-B1305 盐酸氯吡胺 6170-42-9 50mg 600
2024-01-25 HY-B1305 盐酸氯吡胺 6170-42-9 10mM * 1mLin DMSO 660

盐酸氯吡胺 上下游产品信息

上游原料

盐酸氯吡胺供应商 更多

广州爱纯医药科技有限公司
联系电话:020-39119399 18927568969
产品介绍:
中文名称:盐酸氯吡胺
英文名称:Chloropyramine hydrochloride
CAS:6170-42-9
纯度:99.0%
包装信息:50MG; 250MG; 1G; 5G; 10G; 100G
备注:品牌:StdSun | 提供定制合成服务(包括:小分子,药物杂质及医药中间体)
上海超岚化工科技中心
联系电话:QQ:65489617 15618227136
产品介绍:
中文名称:氯吡拉敏盐酸盐
CAS:6170-42-9
纯度:98% HPLC
包装信息:5MG;10MG;50MG;100MG,1G,5G
北京索莱宝科技有限公司
联系电话:010-50973185 4009686088
产品介绍:
中文名称:盐酸氯吡胺
CAS:6170-42-9
江苏艾康生物医药研发有限公司
联系电话:025-66113011 18112977050
产品介绍:
英文名称:Chloropyramine hydrochloride
CAS:6170-42-9
纯度:95% HPLC or GC
包装信息:10G,5G;1G
石家庄革局化工科技有限公司
联系电话: 13020863400
产品介绍:
CAS:6170-42-9
纯度:98% by HPLC
包装信息:1g/;100g/;1kg/;100kg/
备注:可以任意规格分装

最新发布供应信息

6170-42-9;盐酸氯吡胺
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