Precursor of cefcapene diisopropylanmine salt

Product NamePrecursor of cefcapene diisopropylanmine salt
CAS153012-37-4
MFC29H43N5O8S2
MW653.81042
EINECS604-880-2
MOL File153012-37-4.mol

Chemical Properties

InChIKey

IAVQLVKSVQCUFH-SQQJSBOGSA-N

Usage And Synthesis

Preparation

Precursor of cefcapene diisopropylanmine salt (BCN) is an important intermediate in the synthesis of cefcardine hydrochloride. Starting with 7-aminocephalosporanic acid, it undergoes hydrolysis to yield 3-deacetyl-7-aminocephalosporanic acid, which is then reacted with (Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-2-pentenoic acid and diisopropylamine to obtain Precursor of cefcapene diisopropylanmine salt. The overall yield is over 70%, and the purity is over 98%.

Description

The precursor of Boc-Cefcapene(BCN) is a key intermediate in the synthesis of Cefcapene. Cefcapene is a fourth generation cephalosporin antibiotic, which introduces protective groups on its side chain amino group and the carboxyl group of the cephalosporin nucleus to obtain the precursor of Boc-Cefcapene(BCN). After modification of the BCN, various Cefcapene drugs can be obtained.

Chemical Properties

Yellowish crystalline powder.

Uses

N-Boc Cefcapene N,N-Diisopropylamine is a precursor of Cefcapene N,N-Diisopropylamine.

Preparation Products And Raw materials

Raw materials

Cefcapene pivoxil impurity Cefcapene Impurity 1 Hydroxymethyl-7-Aminocephalosporanic acid (Z)-2-(2-tert-Butoxycarbonylaminothiazol-4-yl)-2-pentenoic acid 7-Aminocephalosporanic acid Chlorosulfonyl isocyanate Diisopropylamine