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Cefetamet hydrochloride

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Cefetamet hydrochloride Basic information
Cefetamet hydrochloride Chemical Properties
Safety Information
  • HS Code 2941906000
Cefetamet hydrochloride Usage And Synthesis
  • UsesCefetamet is a third-generation cephalosporin antibiotic and the active agent of Cefeamet pivoxil (C242780) after hydrolysis.
  • Antimicrobial activityA semisynthetic cephalosporin formulated for oral use as the prodrug ester, cefetamet pivoxyl. It is less active than cefaclor and cefadroxil against Staph. aureus, but as active against streptococci and more active against enterobacteria, H. influenzae and N. gonorrhoeae, including β-lactamase-producing strains. L. monocytogenes, C. difficile, Sten. maltophilia and Burk. cepacia are all resistant. It is resistant to hydrolysis by common plasmid-mediated enzymes.
    The absolute bioavailability is about 50%. The plasma peak is delayed by food. Binding to plasma protein is about 20%. The volume of distribution approximates to the extracellular water. It is excreted into urine with a half-life of 2–2.5 h, principally in the glomerular filtrate. Elimination is linearly related to creatinine clearance. Side effects and uses are similar to those of other group 5 cephalosporins.
Cefetamet hydrochloride Preparation Products And Raw materials
Cefetamet hydrochloride(65052-63-3)Related Product Information
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