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CEPHALEXIN MONOHYDRATE

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CEPHALEXIN MONOHYDRATE Basic information
CEPHALEXIN MONOHYDRATE Chemical Properties
  • refractive index 154 ° (C=0.5, H2O)
  • storage temp. Keep in dark place,Sealed in dry,Room Temperature
  • solubility NH4OH 1 M: 50 mg/mL, clear, yellow
  • form solid
  • Water Solubility 13.5g/L(25 ºC)
  • Merck 14,1974
  • BRN 965503
  • InChIKeyAVGYWQBCYZHHPN-KJTIIWGRSA-N
  • CAS DataBase Reference23325-78-2(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 42/43
  • Safety Statements 22-36/37-45-24/25
  • WGK Germany 3
  • RTECS XI0350000
  • HS Code 29419052
  • ToxicityLD50 in mice, rats (g/kg): 1.6-4.5, >5.0 orally; 0.4-1.3, >3.7 i.p. (Welles)
MSDS
CEPHALEXIN MONOHYDRATE Usage And Synthesis
  • Chemical PropertiesWhite to Off-White Solid
  • OriginatorCeporex,Glaxo,UK,1970
  • UsesSemi-synthetic cephalosporin antibiotic.
  • UsesCephalosporin antibacterial.
  • UsesA semisynthetic cephalorsporin antibiotic.
  • DefinitionChEBI: The hydrate of cephalexin.
  • Manufacturing ProcessTo a 1 liter flask containing dimethylformamide at 0°C, was added 24.8 g sodium N-(2-methoxycarbonyl-1-methylvinyl)-D-α-phenylglycine (prepared from sodium D-α-phenylglycine and methyl acetoacetate). The mixture was cooled to -40°C and methyl chloroformate (7.5 ml) and dimethylbenzylamine (0.26 ml) added. After stirring for 25 minutes, p-nitrobenzyl 7- aminodesacetoxycephalosporanate (32.8 g) in the form of its hydrochloride salt was added, followed by triethylamine (12.1 ml) and dimethylformamide (140 ml) over a period of 20 minutes. The reaction mixture was stirred for 2 hours at -25°C to -35°C, then warmed to 0°C and water (32 ml) added. To the resultant solution, hydrochloric acid (54 ml) was added followed by zinc (21.8 g) in portions over a period of 5 minutes, the temperature being maintained at 5°C to 10°C. Further hydrochloric acid (35 ml) was added and the solution stirred at 15°C to 20°C for 7 hours.
    The pH was adjusted to 3.3 with triethylamine and semicarbazidehydrochloride (9.5 g) added. The mixture was brought back to pH 3 with further triethylamine, then stirred for 30 minutes at pH 3. The resultant mixture was adjusted slowly over 4 hours to pH 6.8 by addition of triethylamine, seeding being carried out when pH 4.5 was reached. The precipitated cephalexin was filtered off, washed with dimethylformamide (200 ml) and the cephalexin recovered, yield 75%.
  • brand nameKeflex (Panixine (Ranbaxy).
  • Therapeutic FunctionAntibiotic
CEPHALEXIN MONOHYDRATE(23325-78-2)Related Product Information
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