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CEPHALEXIN MONOHYDRATE

CEPHALEXIN MONOHYDRATE Structure
CEPHALEXIN MONOHYDRATE
  • CAS No.23325-78-2
  • Chemical Name:CEPHALEXIN MONOHYDRATE
  • CBNumber:CB4153386
  • Molecular Formula:C16H19N3O5S
  • Formula Weight:365.4
  • MOL File:23325-78-2.mol
CEPHALEXIN MONOHYDRATE Property
  • refractive index  :154 ° (C=0.5, H2O)
  • storage temp.  :Keep in dark place,Sealed in dry,Room Temperature
  • solubility  :NH4OH 1 M: 50 mg/mL, clear, yellow
  • form  :solid
  • Water Solubility  :13.5g/L(25 ºC)
  • Merck  :14,1974
  • BRN  :965503
  • InChIKey :AVGYWQBCYZHHPN-KJTIIWGRSA-N
  • CAS DataBase Reference :23325-78-2(CAS DataBase Reference)
  • NCI Drug Dictionary :Keflex
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :42/43
  • Safety Statements  :22-36/37-45-24/25
  • WGK Germany  :3
  • RTECS  :XI0350000
  • HS Code  :29419052
  • Toxicity :LD50 in mice, rats (g/kg): 1.6-4.5, >5.0 orally; 0.4-1.3, >3.7 i.p. (Welles)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
CEPHALEXIN MONOHYDRATE Price More Price(6)
  • Brand: Sigma-Aldrich
  • Product number: C4895
  • Product name : Cephalexin hydrate
  • Purity: first-generation cephalosporin antibiotic
  • Packaging: 5 g
  • Price: $132
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: C0675000
  • Product name : Cephalexin monohydrate
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: c0675000
  • Price: $190
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: C0675000
  • Product name : Cephalexin monohydrate
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: C4895
  • Product name : Cephalexin hydrate
  • Purity: first-generation cephalosporin antibiotic
  • Packaging: 10 g
  • Price: $234
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1099008
  • Product name : Cephalexin
  • Purity: 
  • Packaging: 400mg
  • Price: $366
  • Updated: 2020/08/18
  • Buy: Buy

CEPHALEXIN MONOHYDRATE Chemical Properties,Usage,Production

  • Chemical Properties White to Off-White Solid
  • Originator Ceporex,Glaxo,UK,1970
  • Uses Semi-synthetic cephalosporin antibiotic.
  • Uses Cephalosporin antibacterial.
  • Uses A semisynthetic cephalorsporin antibiotic.
  • Definition ChEBI: The hydrate of cephalexin.
  • Manufacturing Process To a 1 liter flask containing dimethylformamide at 0°C, was added 24.8 g sodium N-(2-methoxycarbonyl-1-methylvinyl)-D-α-phenylglycine (prepared from sodium D-α-phenylglycine and methyl acetoacetate). The mixture was cooled to -40°C and methyl chloroformate (7.5 ml) and dimethylbenzylamine (0.26 ml) added. After stirring for 25 minutes, p-nitrobenzyl 7- aminodesacetoxycephalosporanate (32.8 g) in the form of its hydrochloride salt was added, followed by triethylamine (12.1 ml) and dimethylformamide (140 ml) over a period of 20 minutes. The reaction mixture was stirred for 2 hours at -25°C to -35°C, then warmed to 0°C and water (32 ml) added. To the resultant solution, hydrochloric acid (54 ml) was added followed by zinc (21.8 g) in portions over a period of 5 minutes, the temperature being maintained at 5°C to 10°C. Further hydrochloric acid (35 ml) was added and the solution stirred at 15°C to 20°C for 7 hours.
    The pH was adjusted to 3.3 with triethylamine and semicarbazidehydrochloride (9.5 g) added. The mixture was brought back to pH 3 with further triethylamine, then stirred for 30 minutes at pH 3. The resultant mixture was adjusted slowly over 4 hours to pH 6.8 by addition of triethylamine, seeding being carried out when pH 4.5 was reached. The precipitated cephalexin was filtered off, washed with dimethylformamide (200 ml) and the cephalexin recovered, yield 75%.
  • brand name Keflex (Panixine (Ranbaxy).
  • Therapeutic Function Antibiotic
CEPHALEXIN MONOHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
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23325-78-2, CEPHALEXIN MONOHYDRATERelated Search:
  • CEPHALEXIN HYDRATE
  • CEPHALEXIN MONOHYDRATE
  • CEFALEXIN HYDRATE
  • 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-aminophenylacetylamino-3-methyl-8-oxo-, monohydrate, (6R,7R)-
  • cefalexin monohydrat
  • CEPHALEXIN MONOHYDRATE BP USP GRADE
  • CEFALEXIN MONOHYDRATE
  • KEFLEX
  • Cephalexin monhydrochloride
  • Cephalexin (400 mg)
  • Cephalexin (400 mg)J0D296996ug/mg(an)
  • Cefalexin(coMpacted)
  • Cefalexine Monohydrate
  • [6R-[6alpha,7beta(R*)]]-7-(2-Amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cephalexin Monohydrate USP
  • (6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-me thyl-8-oxo-5-thia-1-azabi
  • Cephalexin Monohydrate (Discontinued See C256800)
  • CEPHALEXIN MONOHYDRATE USP/EP/BP
  • 23325-78-2
  • C16H17N3O4SH2O
  • KEFLEX
  • Antibiotics for Research and Experimental Use
  • beta-Lactams (Antibiotics for Research and Experimental Use)
  • Biochemistry