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Divalproex sodium

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Divalproex sodium Basic information
Divalproex sodium Chemical Properties
Safety Information
  • HS Code 2915900000
Divalproex sodium Usage And Synthesis
  • DescriptionDivalproex is a prodrug form of valproic acid (Item No. 13033) that contains valproic acid and valproate sodium. Formulations containing divalproex exhibit delayed gastrointestinal absorption and are converted to valproic acid in the intestine, which reduces gastric irritation and nervous system side effects. Formulations containing divalproex are widely used for the treatment of seizures and bipolar disorder.
  • Chemical PropertiesWhite Solid
  • OriginatorDepakote,Abbott
  • UsesAntiepileptic; Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.
  • UsesDivalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. In rare cases, it is also used as a treatment for major depressive disorder, and increasingly taken long-term for prevent
  • UsesAnticonvulsant; Bipolar Agent
  • DefinitionChEBI: A mixture of valproic acid and its sodium salt in a 1:1 molar ratio. It is used for the management and treatment of seizure disorders, mania, and prophylactic treatment of migraine headache.
  • Manufacturing ProcessDipropyl acetic acid or valproic acid may be prepared the next way. Propylbromide is mixed with cyanacetic acid in the presence of sodium ethylate, made from absolute ethanol and sodium. By that prepared α,α- dipropylcyanacetic acid ethyl ester is saponified with equimolecular amounts of NaOH to give dipropylacetonitril. The desired dipropylacetic acid is produced by saponification of dipropylacetonitryl with aquatic NaOH. It is colorless liquid. BP 219°-220°C.
    Sodium salt of this acid may be prepared by adding of equivalent of NaOH.
  • brand nameDepakote (Abbott).
  • Therapeutic FunctionAnticonvulsant
Divalproex sodium(76584-70-8)Related Product Information
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