补骨脂定
补骨脂定 性质
| 熔点 | 290-292° |
|---|---|
| 沸点 | 458.8±34.0 °C(Predicted) |
| 密度 | 1.383±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | DMSO：可溶5mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 8.70±0.20(Predicted) |
| 颜色 | 白色至米色 |
| InChIKey | YABIJLLNNFURIJ-UHFFFAOYSA-N |
补骨脂定 用途与合成方法
|
COX-2
|
5-LOX
|
Three breast cancer cell (BCC)populations (ALDH
-
cells, ALDH
+
cells, and commercial BSCSs) are sensitive to Psoralidin treatment (10, 15, 20, and 25 μM; 24 hours) with IC
50
s ranging from 18 to 21 μM; however, the MCF-12A cells were resistant to Psoralidin.
Psoralidin (30 μM; 24 hours) results in a significant induction of apoptosis for ALDH
-
cells, ALDH
+
cells, and commercial BCSCs.
Psoralidin treatment also downregulates NOTCH1 expression in both ALDH
-
and ALDH
+
cells.
Cell Viability Assay
| Cell Line: | ALDH - cells, ALDH + cells, commercial breast cancer stem cells (BSCSs), and normal breast epithelial cells (MCF-12A) |
| Concentration: | 10, 15, 50, and 25 μM |
| Incubation Time: | 24 hours |
| Result: | IC 50 s of 18 to 21 μM for ALDH - cells, ALDH + cells, commercial BCSCs. |
Apoptosis Analysis
| Cell Line: | ALDH - cells, ALDH + cells, and commercial BCSCs |
| Concentration: | 20 and 30 μM |
| Incubation Time: | 24 hours |
| Result: | No significant induction of apoptosis was observed for any of the three cell types following treatment at 20 μM. However, 53.60%, 44.1%, and 45.9% of cells were apoptotic at 30 μMin ALDH - cells, ALDH + cells, and commercial BCSCs, respectively. |
Psoralidin (5 mg/kg) regulates expression of pro-inflammatory cytokines that play an important role in inflammatory diseasesin IR-irradiated lung of BALB/c mouse.
| Animal Model: | BALB/c mice |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal application; 30 min before and 1 h after IR irradiation (20 Gy). |
| Result: | Anti-inflammatory effect in IR-irradiated mice. |
补骨脂定 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-N0232 | 补骨脂定 | 18642-23-4 | 5mg | 600 |
| 2024-11-08 | HY-N0232 | 补骨脂定 | 10 mM * 1 mLin DMSO | 660 |
