考迈斯托醇
考迈斯托醇 性质
| 熔点 | ≥350 °C(lit.) |
|---|---|
| 沸点 | 331.39°C (rough estimate) |
| 密度 | 1.2586 (rough estimate) |
| 折射率 | 1.7680 (estimate) |
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于DMSO |
| 形态 | 浅米色固体。 |
| 酸度系数(pKa) | 8.25±0.20(Predicted) |
| 颜色 | 淡黄色至深棕色 |
| BRN | 266702 |
| LogP | 2.940 (est) |
| CAS 数据库 | 479-13-0(CAS DataBase Reference) |
| EPA化学物质信息 | Coumestrol (479-13-0) |
考迈斯托醇 用途与合成方法
IC50: 50 μM
Coumestrol exerts chemotherapeutic effects via PI3K and ERK1/2 MAPK pathways. Coumestrol inhibits viability and invasion, and induces apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of proliferation of ovarian carcinoma, are attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2 and p90RSK is inactivated by coumestrol treatment in a dose- and time-dependent manner. Coumestrol inhibits proliferation and induces apoptosis in MCF-7 cells, which is prevented by copper chelator neocuproine and ROS scavengers. Coumestrol treatment induces ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation.
考迈斯托醇 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-N2335 | 1 mg | 419 | ||
| 2024-11-08 | HY-N2335 | 考迈斯托醇 | 479-13-0 | 5mg | 950 |
