ANKAFLAVIN

Ankaflavin (AK), isolated from Monascus-Fermented red rice, is a PPARγ agonist with anti-inlfammatory activity. Ankaflavin is an active compound having anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.

Ankaflavin was found to be toxic to human cancer cell lines Hep G2 and A549 with a similar IC50 value of 15 μg/mL, while it posed no significant toxicity to normal MRC-5 and WI-38 cells at the same concentration.Ankaflavin exhibits selective cytotoxic effect and induces cell death on cancer cells.

Ankaflavin is a microbial metabolite that has been found in M. ruber and has diverse biological activities.1,2,3 It induces cytotoxicity in HepG2 hepatic carcinoma and A549 lung cancer cells (IC50 = ~15 µg/ml for both).1 Ankaflavin (15 µg/ml) induces cell cycle arrest at the G0 phase in HepG2 cells. It reduces nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophages when used at concentrations of 5, 10, and 15 µg/ml.2 Ankaflavin (10 µM) increases lipolysis in 3T3-L1 adipocytes matured by isobutylmethylxanthine (IBMX; Item No. 13347), dexamethasone (Item No. 11015), and insulin.3 In vivo, ankaflavin (5 mg/kg per day) reduces blood glucose and serum insulin levels in mice fed a high-fat diet.WARNING This product is not for human or veterinary use.