苯并(a)芘
苯并(a)芘 性质
| 熔点 | 177-180°C |
|---|---|
| 沸点 | 495°C |
| 密度 | 1.1549 (estimate) |
| 蒸气压 | 2.4 at 25 °C (McVeety and Hites, 1988) |
| 折射率 | 1.8530 (estimate) |
| 闪点 | 495°C |
| 储存条件 | 2-8°C |
| 溶解度 | Soluble in benzene, toluene, and xylene; sparingly soluble in ethanol and methanol (Windholz et al., 1983) |
| 形态 | 结晶 |
| 酸度系数(pKa) | >15 (Christensen et al., 1975) |
| 颜色 | 淡黄色/绿色/橙色 |
| 水溶解性 | Soluble in benzene, toluene, and xylene. Sparingly soluble in alcohol, methanol. Insoluble in water |
| Merck | 14,1103 |
| BRN | 1911333 |
| Henry's Law Constant | 7.35 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)(x 10-10 mmHg at 25 °C): |
| 暴露限值 | OSHA: TWA 0.2 mg/m3 |
| 稳定性 | 稳定的。与强氧化剂不相容。 |
| InChIKey | FMMWHPNWAFZXNH-UHFFFAOYSA-N |
| CAS 数据库 | 50-32-8(CAS DataBase Reference) |
| (IARC)致癌物分类 | 1 (Vol. Sup 7, 92, 100F) 2012 |
| EPA化学物质信息 | Benzo[a]pyrene (50-32-8) |
苯并(a)芘 用途与合成方法
苯并芘（Benzopyrene），它是由一个苯环和一个芘分子结合而成的多环芳烃类化合物，是一种常见的高活性间接致癌物，是目 前世界三大强致癌物之一。根据国家《食用植物油卫生标准》，食用油中 苯并芘含量的最高上限为10微克/千克。苯并[a]芘是一种具有潜在的致癌、致畸和致突变作用的5环结构多环芳烃。
苯并(a)芘是世界公认的强致癌性多环芳烃污染物，这是因为其自身具有五环结构，因此能积累在生物体中，导致生物染色体发生畸变，无序合成DNA，进而威 胁到人类健康。苯并(a)芘在环境中分布很广。 Benzo[a]pyrene 在动物模型中显示肺致癌性，并且它们经常用于化学预防研究。Statistically significant decrease is observed at 7 weeks in females receiving 1.0 mg Benzo[a]pyrene (B[a]P) compare with the vehicle group. As lung tumorigenesis induced by Benzo[a]pyrene is dose dependent in female A/J mice. The incidence of hyperplasia values in females treating with 0.25, 0.50, and 1.0 mg Benzo[a]pyrene are significantly higher than in the vehicle-treated group. The incidence of adenoma in females receiving 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of hyperplasia in females receiving 0.50 or 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of adenoma in the group treated with 1.0 mg is also significantly higher than in the vehicle group. The incidences of hyperplasia and adenoma in female A/J mice are significantly increased by Benzo[a]pyrene in a dose-dependent manner. Benzo[a]pyrene induces an average of 9.38±1.75 tumors with an average tumor load of 19.53±3.81 mm 3 (P<0.05 compare to control). Benzo[a]pyrene administration significantly (P<0.05) decreases cAMP levels in tumors with adjacent lung tissues. The expression level of PDE4D gene is also increased by Benzo[a]pyrene administration.
安全信息
| 危险品标志 | T,N,F |
|---|---|
| 危险类别码 | 45-46-50/53-60-61-43-67-66-36-11-65-38-52/53-36/37/38 |
| 安全说明 | 45-53-61-60-26-62-16 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| RTECS号 | DJ3675000 |
| TSCA | Yes |
| 危险等级 | 6.1 |
| 包装类别 | III |
| 海关编码 | 29029090 |
| 毒害物质数据 | 50-32-8(Hazardous Substances Data) |
| 毒性 | LD50 for mice (intraperitoneal) 232 mg/kg (Salamone, 1981). |
苯并(a)芘 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | 015856 | 苯并[a]芘, 96% | 50-32-8 | 100mg | 1115 |
| 2024-11-08 | 015856 | 苯并[a]芘 | 50-32-8 | 0.5g | 4457 |
