50-32-8
基本信息
苯并(a)芘
苯并[A]芘
苯并芘
1,2-苯并芘
苯并芘标准品
苯并芘 停产
苯并(A)芘(标样)3,4-BENZOPYRENE
稠环芳烃
苯駢
3,4-苯并花
3,4-BENZPYRENE
3，4-Benzypyrene
6,7-BENZOPYRENE
BACTERIAL ALKALINE PHOSPHATASE
BACTERIAL PHOSPHATASE, ALKALINE
BAP
BENZ[A]PYRENE
BENZO (ALPHA) PYRENE
BENZO[A]PYRENE
BENZO(DEF)CHRYSENE
BENZOPYRENE
3,4-benz(a)pyrene
3,4-Benz[a]pyrene
3,4-Benzopirene
3,4-Benzpyren
3,4-BP
BP
coaltarpitchvolatiles:benzo(a)pyrene
Rcra waste number U022
物理化学性质
| 外观性质 | 无色至淡黄色、针状、晶体(纯品)。 |
| 溶解性 | 不溶于水，微溶于乙醇、甲醇，溶于苯、甲苯、二甲苯、氯仿、乙醚、丙酮等。 |
| 熔点 | 177-180°C |
| 沸点 | 495°C |
| 密度 | 1.1549 (estimate) |
| 蒸气压 | 2.4 at 25 °C (McVeety and Hites, 1988) |
| 折射率 | 1.8530 (estimate) |
| 闪点 | 495°C |
| 储存条件 | APPROX 4°C |
| 溶解度 | Soluble in benzene, toluene, and xylene; sparingly soluble in ethanol and methanol (Windholz et al., 1983) |
| 酸度系数(pKa) | >15 (Christensen et al., 1975) |
| 形态 | Crystalline |
| 颜色 | 淡黄色/绿色/橙色 |
| 水溶解性 | Soluble in benzene, toluene, and xylene. Sparingly soluble in alcohol, methanol. Insoluble in water |
| Merck | 14,1103 |
| BRN | 1911333 |
| Henry's Law Constant | 7.35 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)(x 10-10 mmHg at 25 °C): |
| 暴露限值 | OSHA: TWA 0.2 mg/m3 |
| 稳定性 | 稳定的。与强氧化剂不相容。 |
| InChIKey | FMMWHPNWAFZXNH-UHFFFAOYSA-N |
| CAS 数据库 | 50-32-8(CAS DataBase Reference) |
| (IARC)致癌物分类 | 1 (Vol. Sup 7, 92, 100F) 2012 |
| EPA化学物质信息 | Benzo[a]pyrene (50-32-8) |
安全数据
| 危险性符号(GHS) |    GHS07,GHS08,GHS09 |
| 警示词 | 危险 |
| 危险性描述 | H317-H340-H350-H360FD-H410 |
| 防范说明 | P202-P261-P273-P280-P302+P352-P308+P313 |
| 危险品标志 | T,N,F |
| 危险类别码 | R45-R46-R50/53-R60-R61-R43-R67-R66-R36-R11-R65-R38 |
| 安全说明 | S45-S53-S61-S60-S26-S62 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| RTECS号 | DJ3675000 |
| TSCA | Yes |
| 危险等级 | 6.1 |
| 包装类别 | III |
| 海关编码 | 29029090 |
| 毒害物质数据 | 50-32-8(Hazardous Substances Data) |
| 毒性 | LD50 for mice (intraperitoneal) 232 mg/kg (Salamone, 1981). |
应用领域
50-32-8(安全特性,毒性,储运)
常见问题列表
苯并芘（Benzopyrene），它是由一个苯环和一个芘分子结合而成的多环芳烃类化合物，是一种常见的高活性间接致癌物，是目 前世界三大强致癌物之一。根据国家《食用植物油卫生标准》，食用油中 苯并芘含量的最高上限为10微克/千克。苯并[a]芘是一种具有潜在的致癌、致畸和致突变作用的5环结构多环芳烃。
Statistically significant decrease is observed at 7 weeks in females receiving 1.0 mg Benzo[a]pyrene (B[a]P) compare with the vehicle group. As lung tumorigenesis induced by Benzo[a]pyrene is dose dependent in female A/J mice. The incidence of hyperplasia values in females treating with 0.25, 0.50, and 1.0 mg Benzo[a]pyrene are significantly higher than in the vehicle-treated group. The incidence of adenoma in females receiving 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of hyperplasia in females receiving 0.50 or 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of adenoma in the group treated with 1.0 mg is also significantly higher than in the vehicle group. The incidences of hyperplasia and adenoma in female A/J mice are significantly increased by Benzo[a]pyrene in a dose-dependent manner. Benzo[a]pyrene induces an average of 9.38±1.75 tumors with an average tumor load of 19.53±3.81 mm 3 (P<0.05 compare to control). Benzo[a]pyrene administration significantly (P<0.05) decreases cAMP levels in tumors with adjacent lung tissues. The expression level of PDE4D gene is also increased by Benzo[a]pyrene administration.
知名试剂公司产品信息
Benzo[a]pyrene, 96%(50-32-8) Alfa Aesar
3,4-Benzopyrene,>95.0%(GC)(50-32-8) TCI Shanghai