4-Bromo-2-chlorobenzonitrile is used as a intermediate in organic synthesis and a ligand in transition metal complexes.
4-Bromo-2-chlorobenzonitrile is used as a pharmaceutical intermediate in oncology research. This compound is used in the preparation of darolutamide, a non-steroidal antiandrogenic drug used in the treatment of non-metastatic and metastatic castration-resistant prostate cancer.
4-Bromo-2-chlorobenzonitrile is prepared by a two-step reaction of reacting 4-bromo-2-chlorobenzaldehyde and sodium cyanide in aqueous solution.
[1] Medicinal Chemistry Research, 2016, vol. 25, # 4, p. 539 - 552
