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N-EPSILON-ACETYL-L-LYSINE

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N-EPSILON-ACETYL-L-LYSINE Basic information
N-EPSILON-ACETYL-L-LYSINE Chemical Properties
  • Melting point:250 °C (dec.)(lit.)
  • Boiling point:323.23°C (rough estimate)
  • Density 1.1793 (rough estimate)
  • refractive index 1.4500 (estimate)
  • storage temp. -20°C
  • form Powder
  • pka2.53±0.24(Predicted)
  • color White
  • Water Solubility Soluble in water (miscible), and 80% acetic acid (50 mg/ml).
  • Sensitive Hygroscopic
  • InChIKeyDTERQYGMUDWYAZ-ZETCQYMHSA-N
  • CAS DataBase Reference692-04-6(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 24/25-36-26
  • WGK Germany 3
  • HS Code 29241900
MSDS
N-EPSILON-ACETYL-L-LYSINE Usage And Synthesis
  • DescriptionAcetyllysine (or acetylated lysine) is an acetyl-derivative of the amino acid lysine. There are multiple forms of acetyllysine - this article refers to N-ε-acetyl-L-lysine. The other form is N-α-acetyl-Llysine.
    In proteins, the acetylation of lysine residues is an important mechanism of epigenetics. It functions by regulating the binding of histones to DNA in nucleosomes and thereby controlling the expression of genes on that DNA. Non-histone proteins are acetylated as well. Unlike the functionally similar methyllysine, acetyllysine does not carry a positive charge on its side chain.
    Histone acetyltransferases (HATs) catalyze the addition of acetyl groups from acetyl-CoA onto certain lysine residues of histones and non-histone proteins. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from acetylated lysines.
    Acetyllysine can be synthesized from lysine by the selective acetylation of the terminal amine group.
  • Chemical Propertieswhite crystalline powder
  • DefinitionChEBI: An N6-acyl-L-lysine where the N6-acyl group is specified as acetyl.
N-EPSILON-ACETYL-L-LYSINE(692-04-6)Related Product Information
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