Lucidadiol

Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC50 values of 31 μM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1[1][2].

AChE: 31.03 μM (IC₅₀); BChE: 156.27 μM (IC₅₀)

[1] Iksoo Lee, et al. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6603-7. DOI:10.1016/j.bmcl.2011.04.042
[2] Lee I,et al. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum [published correction appears in Bioorg Med Chem Lett. 2013 Nov 15;23(22):6199-200]. Bioorg Med Chem Lett. 2011;21(21):6603-6607. DOI:10.1016/j.bmcl.2011.04.042
[3] Mothana RA,et al. Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi. Fitoterapia. 2003;74(1-2):177-180. DOI:10.1016/s0367-326x(02)00305-2