Tenovin-6 Hydrochloride, is a small molecule activator of p53 transcriptional activity. It acts as a potent SIRT1 and SIRT2 inhibitor as well.
ChEBI: Tenovin-6 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(dimethylamino)pentanoic acid with the aromatic amino group of N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide. It has a role as an antineoplastic agent, a Sir2 inhibitor and a p53 activator. It is a monocarboxylic acid amide, a member of thioureas and a tertiary amino compound.
Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1].
SIRT2: 10 μM (IC50); SIRT1: 21 μM (IC50); SIRT3: 67 μM (IC50); HDAC8; MDM-2/p53
