Basic information Abstract Biological activity In vitro In vivo Features References Safety Related Supplier
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Veliparib

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments. Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.

Basic information Abstract Biological activity In vitro In vivo Features References Safety Related Supplier
Veliparib Basic information
Veliparib Chemical Properties
  • Boiling point:579.0±40.0 °C(Predicted)
  • Density 1.274
  • pka9.22±0.30(Predicted)
  • CAS DataBase Reference912444-00-9
Veliparib Usage And Synthesis
  • AbstractVeliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments.
    Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.
  • Biological activityVeliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
  • In vitroVeliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor,which inhibits PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays,respectively.ABT-888 reduces clonogenic survival and inhibits DNA repair in H460 cells. ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells.
  • In vivoABT-888 inhibits PARP in B16F10 and 9L xenograft models, thus enhancing the anticancer activity of temozolomide. The Combined with other cytotoxic agents, ABT-888 shows strong antitumor effect in MX-1 xenograft model. ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg according to the the size of tumors in A375 and Colo829 xenograft models.
  • FeaturesABT-888 enhances the effectiveness of common cancer treatments, such as radiation therapy and alkylating agents.
  • Referenceshttps://www.abbvie.com/our-science/pipeline/veliparib.html
    https://en.wikipedia.org/wiki/Veliparib
  • Chemical PropertiesOff-White Solid
  • UsesABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
  • DefinitionChEBI: A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor.
Veliparib(912444-00-9)Related Product Information
VeliparibSupplierMore
  • Company Name:Changzhou Josen Pharmaceutical Chemical Co., Ltd. Gold
  • Tel:0519-85286950 15380036950
  • Email:info@josenchem.com
  • Products Intro:Product Name:ABT-888
    CAS:912444-00-9
    Purity:HPLC:99.0%
  •  
  • Company Name:Hangzhou J&H Chemical Co., Ltd. Gold
  • Tel:0571-87396432-
  • Email:sales@jhechem.com;
  • Products Intro:Product Name:Veliparib or (R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide
    CAS:912444-00-9
    Purity:98%min Package:1kg/ Remarks:1g,5g,10g,25g,100g,500g,1kg,25kg or on request
  •  
  • Company Name:Shanghai Boyle Chemical Co., Ltd.
  • Tel:
  • Email:sales@boylechem.com
  • Products Intro:Product Name:2-(2R)-2-Methylpyrrolidin-2-yl-1H-benimidazole-4- carboxamide
    CAS:912444-00-9
  •  
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Email:jkinfo@jkchemical.com;market6@jkchemical.com
  • Products Intro:Product Name:ABT 888
    CAS:912444-00-9
    Package:100Mg,10Mg,25Mg
  •  
  • Company Name:Chembest Research Laboratories Limited
  • Tel:021-20908456-
  • Email:sales@BioChemBest.com
  • Products Intro:Product Name:ABT-888(Veliparib)
    CAS:912444-00-9
    Purity:98% Package:50mg;100mg;500mg;1g;5g;10g Remarks:C13250
  •