Basic information Abstract Biological activity In vitro In vivo Features References Safety Related Supplier
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2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments. Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.

Basic information Abstract Biological activity In vitro In vivo Features References Safety Related Supplier
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide Basic information
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide Chemical Properties
  • Boiling point:579.0±40.0 °C(Predicted)
  • Density 1.274
  • pka9.22±0.30(Predicted)
  • CAS DataBase Reference912444-00-9
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide Usage And Synthesis
  • AbstractVeliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments.
    Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.
  • Biological activityVeliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
  • In vitroVeliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor，which inhibits PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays，respectively.ABT-888 reduces clonogenic survival and inhibits DNA repair in H460 cells. ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells.
  • In vivoABT-888 inhibits PARP in B16F10 and 9L xenograft models, thus enhancing the anticancer activity of temozolomide. The Combined with other cytotoxic agents, ABT-888 shows strong antitumor effect in MX-1 xenograft model. ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg according to the the size of tumors in A375 and Colo829 xenograft models.
  • FeaturesABT-888 enhances the effectiveness of common cancer treatments, such as radiation therapy and alkylating agents.
  • Referenceshttps://www.abbvie.com/our-science/pipeline/veliparib.html
    https://en.wikipedia.org/wiki/Veliparib
  • Chemical PropertiesOff-White Solid
  • UsesABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
  • DefinitionChEBI: A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor.
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide(912444-00-9)Related Product Information
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamideSupplierMore
  • Company Name:Changzhou Josen Pharmaceutical Chemical Co., Ltd. Gold
  • Tel:0519-85286950 15380036950
  • Email:info@josenchem.com
  • Products Intro:Product Name:ABT-888
    CAS:912444-00-9
    Purity:HPLC：99.0%
  •  
  • Company Name:Shanghai Chainpharm Bio-medical Technology Co., Ltd. Gold
  • Tel:13611721451
  • Email:sales@chainpharm.com;
  • Products Intro:Product Name:2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-beniMidazole-4-carboxaMide
    CAS:912444-00-9
    Package:1g,5g,10g,25g,100g,500g,1kg,25kg or on request
  •  
  • Company Name:Hangzhou J&H Chemical Co., Ltd. Gold
  • Tel:
  • Email:sales@jhechem.com;
  • Products Intro:Product Name:Veliparib or (R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide
    CAS:912444-00-9
    Purity:98%min Package:1kg/ Remarks:1g,5g,10g,25g,100g,500g,1kg,25kg or on request
  •  
  • Company Name:Shanghai Boyle Chemical Co., Ltd.
  • Tel:
  • Email:sales@boylechem.com
  • Products Intro:Product Name:2-(2R)-2-Methylpyrrolidin-2-yl-1H-benimidazole-4- carboxamide
    CAS:912444-00-9
  •  
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Email:jkinfo@jkchemical.com;market6@jkchemical.com
  • Products Intro:Product Name:ABT 888
    CAS:912444-00-9
    Package:100Mg,10Mg,25Mg
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