ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > DNA damage > PARP inhibitors > Veliparib
Veliparib
Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments. Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.
Basic information
Abstract Biological activity In vitro In vivo Features References
Safety
Related
Supplier
- Product Name:Veliparib
- CAS:912444-00-9
- MF:C13H16N4O
- MW:244.29
- EINECS:681-636-1
- Mol File:912444-00-9.mol
-
Veliparib Chemical Properties
- Boiling point:579.0±40.0 °C(Predicted)
- Density 1.274
- pka9.22±0.30(Predicted)
- CAS DataBase Reference912444-00-9
Veliparib Usage And Synthesis
- AbstractVeliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments.
Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer. - Biological activityVeliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
- In vitroVeliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor，which inhibits PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays，respectively.ABT-888 reduces clonogenic survival and inhibits DNA repair in H460 cells. ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells.
- In vivoABT-888 inhibits PARP in B16F10 and 9L xenograft models, thus enhancing the anticancer activity of temozolomide. The Combined with other cytotoxic agents, ABT-888 shows strong antitumor effect in MX-1 xenograft model. ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg according to the the size of tumors in A375 and Colo829 xenograft models.
- FeaturesABT-888 enhances the effectiveness of common cancer treatments, such as radiation therapy and alkylating agents.
- Referenceshttps://www.abbvie.com/our-science/pipeline/veliparib.html
https://en.wikipedia.org/wiki/Veliparib - Chemical PropertiesOff-White Solid
- UsesABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
- DefinitionChEBI: A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor.
- Niraparib ABT-888 Chidamide Capecitabine 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Bortezomib PF-01367338 MK-2206 2HCl Talazoparib (BMN 673) N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Olaparib
VeliparibSupplierMore
- Company Name:Changzhou Josen Pharmaceutical Chemical Co., Ltd. Gold
- Tel:0519-85286950 15380036950
- Email:info@josenchem.com
- Products Intro:Product Name:ABT-888
CAS:912444-00-9
Purity:HPLC：99.0%
- Company Name:Hangzhou J&H Chemical Co., Ltd. Gold
- Tel:0571-87396432-
- Email:sales@jhechem.com;
- Products Intro:Product Name:Veliparib or (R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide
CAS:912444-00-9
Purity:98%min Package:1kg/ Remarks:1g,5g,10g,25g,100g,500g,1kg,25kg or on request
- Company Name:Shandong Chenxi Pharmaceutical Co., Ltd. Gold
- Tel:13153166250
- Email:sales@chemedpharma.com;
- Products Intro:Product Name:Veliparib
CAS:912444-00-9
Purity:99.0% Package:1KG/
- Company Name:Shanghai Boyle Chemical Co., Ltd.
- Tel:
- Email:sales@boylechem.com
- Products Intro:Product Name:2-(2R)-2-Methylpyrrolidin-2-yl-1H-benimidazole-4- carboxamide
CAS:912444-00-9
- Company Name:J & K SCIENTIFIC LTD.
- Tel:400-666-7788 010-82848833-
- Email:jkinfo@jkchemical.com;market6@jkchemical.com
- Products Intro:Product Name:ABT 888
CAS:912444-00-9
Package:100Mg,10Mg,25Mg