Basic information Description In vitro Safety Related Supplier
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ABT 263

Basic information Description In vitro Safety Related Supplier
ABT 263 Basic information
ABT 263 Chemical Properties
  • Melting point:114-116°C
  • Density 1.41±0.1 g/cm3(Predicted)
  • storage temp. -20°C Freezer, Under Inert Atmosphere
  • pka4.60±0.10(Predicted)
  • CAS DataBase Reference923564-51-6
Safety Information
  • HS Code 29339900
ABT 263 Usage And Synthesis
  • DescriptionABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.
  • In vitroABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263.
  • Chemical PropertiesPale Yellow Solid
  • UsesABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.
  • UsesA novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.
ABT 263(923564-51-6)Related Product Information
ABT 263SupplierMore
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  • Products Intro:Product Name:Navitoclax
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  • Products Intro:Product Name:Navitoclax(ABT-263)
    CAS:923564-51-6
    Purity:98% Package:1G; 25G; 1KG; 25KG
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