2-Bromo-1-(3-fluorophenyl)ethan-1-one

455-36-7

53631-18-8

GENERAL METHODS: Oxone (1.352 g, 2.2 mmol) was added to a well-stirred methanol (10 mL) solution of m-fluoroacetophenone (2 mmol) and NH4Br (0.215 g, 2.2 mmol) and the reaction mixture was stirred at room temperature (or reflux temperature). The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was quenched with aqueous sodium thiosulfate and extracted with ethyl acetate (3 × 25 mL). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuum to remove the solvent to give the crude product. The crude product was further purified by silica gel column chromatography (200-300 mesh) to give pure 2-bromo-3'-fluoroacetophenone. All products were structurally confirmed by 1H NMR and mass spectrometry data.