Trifluoroacetophenone

CLEAR COLORLESS TO YELLOW LIQUID

2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptosis in cerebellar granule neurons.

2,2,2-Trifluoroacetophenone is the starting material for the synthesis of f 3-trifluoromethyl-3-phenyldiazirine. It undergoes asymmetric reduction with optically active Grignard reagent to form 2,2,2-trifluoro-1-phenylethanol. It undergoes condensation with biphenyl, terphenyl, a mixture of biphenyl with terphenyl, phenyl ether and diphenoxybenzophenone to form new aromatic 3F polymers.

2,2,2-Trifluoroacetophenone is commonly synthesized by the following methods: (1) Trifluoroacetic acid is directly synthesized in one step by reacting directly with the Grignard reagent of bromobenzene. The yield is about 60%. The advantages of this method are simple operation and cheap raw materials. Disadvantages: exothermic and low yield. (2) in -40 ??, carbon disulfide solvent, the role of Lewis acid AlCl3, trifluoroacetic anhydride and the benzene ring to pay the acylation reaction preparation, yield of about 70%. Advantages of the method: one-step synthesis. Disadvantages: solvent toxicity, AlCl3 is difficult to deal with, the use of strong acid, strong alkali corrosion equipment and pollution of the environment. (3) Trifluoromethane gas and benzoate or benzoyl chloride reaction, preparation. Yield 70-80%.