asebogenin

Asebogenin has antimalarial activity in vitro[1]. Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps[2].

ChEBI: A member of the class of dihydrochalcones that is the 4'-methyl ether derivative of phloretin.

[1] 1.Jenett-Siems K, et al. n vitro antiplasmodial activity of Central American medicinal plants. Trop Med Int Health. 1999 Sep;4(9):611-5. DOI:10.1046/j.1365-3156.1999.00456.x
[2] Li L, et al. Asebogenin suppresses thrombus formation via inhibition of Syk phosphorylation. Br J Pharmacol. 2023 Feb;180(3):287-307. DOI:10.1111/bph.15964