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Methylthiouracil Basic information
Methylthiouracil Chemical Properties
Safety Information
  • Hazard Codes Xn,Xi
  • Risk Statements 22-40
  • Safety Statements 36/37-45
  • RIDADR UN 3077 9 / PGIII
  • WGK Germany 3
  • RTECS YR0875000
  • Hazard Note Irritant/Possible Carcinogen
  • TSCA Yes
  • HS Code 29335995
  • Hazardous Substances Data56-04-2(Hazardous Substances Data)
  • ToxicityMLD in rabbits (mg/kg): 2486 orally (Simon)
Methylthiouracil Usage And Synthesis
  • Chemical Propertieswhite powder
  • Usesantithyroid agent
  • General DescriptionWhite crystalline powder with an odor of onions and a bitter taste. A saturated aqueous solution is neutral or slightly acidic.
  • Air & Water ReactionsInsoluble in water.
  • Reactivity ProfileMethylthiouracil reacts with strong oxidizing agents. Forms complexes with metals and is oxidized by iodine and other sulfhydryl oxidizing agents .
  • Fire HazardFlash point data for Methylthiouracil are not available. Methylthiouracil is probably combustible.
  • Safety ProfileConfirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human teratogenic and reproductive effects by an unspecified route: developmental abnormalities of the endocrine system and effects on newborn including neonatal measures or effects. Experimental reproductive effects. Used to treat hyperthyroidism. When heated to decomposition it emits very toxic fumes of NOx and SOx.
  • Purification MethodsCrystallise the thiouracil from a large volume of H2O. Purify it further by dissolving in base, adding charcoal, filtering and acidifying with AcOH. Suspend the wet solid (ca 100g) in boiling H2O (1L), stir and add AcOH (20mL), stir and refrigerate. Collect the product, wash it with cold H2O (4 x 200mL), drain it for several hours then place it in an oven at 70o to constant weight. [IR: Short & Thompson J Chem Soc 168 1952, Foster & Snyder Org Synth Coll Vol IV 638 1063, Beilstein 24 III/IV 1289.]
Methylthiouracil Preparation Products And Raw materials
Methylthiouracil(56-04-2)Related Product Information
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