托麦汀
托麦汀 性质
| 熔点 | 156 °C |
|---|---|
| 沸点 | 400.53°C (rough estimate) |
| 密度 | 1.1391 (rough estimate) |
| 折射率 | 1.5200 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | pKa 3.5(H2O t undefined I undefined) (Uncertain) |
| 颜色 | 灰白色至浅黄色 |
| 水溶解性 | 222 mg/L |
| InChI | InChI=1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18) |
| InChIKey | UPSPUYADGBWSHF-UHFFFAOYSA-N |
| SMILES | N1(C)C(C(=O)C2=CC=C(C)C=C2)=CC=C1CC(O)=O |
| NIST化学物质信息 | Tolmetin(26171-23-3) |
| EPA化学物质信息 | 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)- (26171-23-3) |
托麦汀 用途与合成方法
|
Human COX-1 0.35 μM (IC 50 ) |
Human COX-2 0.82 μM (IC 50 ) |
Tolmetin (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin (0-100 μM) shows no effect on osteoblast growth.
Tolmetin (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.
托麦汀 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-03-03 | S4832 | 托麦汀 | 26171-23-3 | 25mg | 795.02 |
| 2026-03-03 | S4832 | 托麦汀 | 26171-23-3 | 1g | 3031.12 |
