Prevention and treatment of cardiovascular complications
of aging, diabetes, and end stage renal disease;
diabetic multisymptom pathology (other than cardiovascular)
including retinopathy, neuphropathy, neuropathy, and
ulcers (advanced glycosylation endpr.
Alagebrium Chloride is used in the treatment of obesity resulting from a diet high in both fat and AGE that causes renal impairment in animals. Alagebrium inhibits AGE-mediated formation of reactive oxygen species (ROS), extracellular signal-regulated kinase phosphorylation, and cyclooxygenase-2 expression.
