4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物
4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物
4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 性质
| 熔点 | 212 °C(dec.) |
|---|---|
| 储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| Merck | 14,203 |
| InChI | InChI=1S/C13H14NOS.ClH/c1-10-11(2)16-9-14(10)8-13(15)12-6-4-3-5-7-12;/h3-7,9H,8H2,1-2H3;1H/q+1;/p-1 |
| InChIKey | MKOMESMZHZNBIZ-UHFFFAOYSA-M |
| SMILES | C([N+]1=CSC(C)=C1C)C(C1C=CC=CC=1)=O.[Cl-] |
| CAS 数据库 | 341028-37-3(CAS DataBase Reference) |
4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 用途与合成方法
AGE
Alagebrium chloride is an advanced glycation end product ( AGE ) inhibitor. Endothelial cell (EC) proliferation is increased for all groups receiving Alagebrium (ALT-711), particularly when seeded on matrix from the AAo of obese (ZO) and diabetic (ZD) rats.
Blood pressure is not affected by treatment with Alagebrium. In diabetic RAGE apoE double-KO mice, treatment with Alagebrium is associated with a modest reduction in renal mass and reduces hyperfiltration compare with nontreated mice. Treatment with Alagebrium in diabetic RAGE apoE double-KO mice is associated with a further reduction in glomerular collagen IV levels, approaching levels observed in control mice. Body weight, heart rate (HR), and mean blood pressure (BP) are similar in Zucker lean (ZL), obese (ZO), and diabetic (ZD) groups in the absence or presence of Alagebrium (ALT-711). Alagebrium increases blood flow (BF) in ZO rats but reduces distal vascular resistance in ZD rats. A decrease in neointimal hyperplasia (NH) intrastrut thickness as a function of local radius is found in all groups with Alagebrium treatment. A significant increase in TGF-β expression is also found in the AAo of ZL rats treated with Alagebrium.
4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-10-13 | XW0234102837304 | 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 | 341028-37-3 | 5G | 903 |
| 2026-10-13 | XW0234102837303 | 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 | 341028-37-3 | 1G | 218 |
