N-(4-Nitrophenyl)propionamide

79-03-8

100-01-6

4850-93-5

General procedure for the synthesis of p-nitropropionanilide from propionyl chloride and 4-nitroanilide: To a solution of 4-nitroanilide (7.5 mmol, 1.04 g) in dichloromethane (30 mL) was slowly added propionyl chloride (7.5 mmol, 0.70 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure by rotary evaporator to remove the solvent. The crude product was washed with hexane (10 mL) to remove impurities. Finally, the product was dried under vacuum to afford the target compound N-(4-nitrophenyl)propionamide in white powder form in a yield of 0.38 g (26% yield).