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GOSSYPOL

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GOSSYPOL Basic information
GOSSYPOL Chemical Properties
  • Melting point:181-183 C
  • Boiling point:522.63°C (rough estimate)
  • Density 1.1912 (rough estimate)
  • refractive index 1.4900 (estimate)
  • storage temp. 2-8°C
  • form Off-white to yellow solid.
  • pka7.15±0.50(Predicted)
  • Water Solubility Soluble in 100%ethanol (25 mg/ml), DMF (25 mg/ml), acetone, DMSO (25 mM), methanol (2 mg/ml), ether, chloroform, sodium carbonate, and dilute aqueous solutions of ammonia . Insoluble in water. Gossypol is a male antifertility agent with antispermatogenic activity and has been shown to contain antitumor, anitviral, and antioxidant properties.
  • InChIKeyQBKSWRVVCFFDOT-UHFFFAOYSA-N
  • CAS DataBase Reference303-45-7
  • EPA Substance Registry System[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)- (303-45-7)
Safety Information
MSDS
GOSSYPOL Usage And Synthesis
  • Chemical PropertiesSoild
  • OccurrenceGossypol is found in cotton and is made synthetically.
  • Usesantispermatogenic, antineoplastic, antiHIV
  • UsesGossypol is a mixture of natural polyphenols isolated from the cotton plant. It causes spermatogenesis arrest in humans and also functions as an anti-malarial agent. Antiinflammatory. Anticancer.
  • HazardToxic by ingestion but is inactivated by heat, 0.04% max allowed in foods.
  • Biological ActivityLipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Pro-apoptotic; downregulates Bcl-2 and Bcl-XL.
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