Name | Gossypol |
Description | Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. |
Cell Research | MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. (Only for Reference) |
In vitro | Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner[1]. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro[2]. |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 50 mg/mL (96.42 mM)
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Keywords | Inhibitor | BL193 | NSC56817 | BL-193 | Gossypol | Bcl-2 Family | inhibit | NSC-56817 |
Inhibitors Related | Disulfiram | Methotrexate | Rotenone | Mycophenolate Mofetil | Ribavirin | Benzyl alcohol | Navitoclax | Venetoclax | Isomalt | Isoniazid | Sodium Oxamate | Ivosidenib |
Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Food as Medicine Compound Library |