3-Bromo-2-chloro-5-nitropyridine is synthesised using 3-Bromo-2-hydroxy-5-nitropyridine as raw material by chemical reaction. The specific synthesis steps are as follows:
Second step POCI3 (3 ml) was added at 0°C to the mixture of 3-Bromo-2-hydroxy-5-nitropyridine (7.25 g, 33 mmol) and quinoline (2 ml, 16.5 mmol). This reaction medium was heated at 12000 for 2.5 hours and then, after cooling to room temperature, 20 ml of water were added. The precipitate formed was collected by filtration and dried to give the expected 3-Bromo-2-chloro-5-nitropyridine in the form of a brown solid, in a yield of 95percent (7.5 g).The NMR analyses (1H 400 MHz DMSO-d6) are in accordance with the expected structure.
