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BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-

Product NameBenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-
CAS300586-90-7
MFC14H11N3O
MW237.26
EINECS
MOL File300586-90-7.mol

Chemical Properties

Boiling point	386.6±22.0 °C(Predicted)
Density	1.363±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
pka	11.76±0.43(Predicted)
form	powder
color	white to beige
InChI	1S/C14H11N3O/c18-14(10-4-2-1-3-5-10)17-13-8-11-6-7-15-12(11)9-16-13/h1-9,15H,(H,16,17,18)
InChIKey	HWJRIFZDXJKJJN-UHFFFAOYSA-N
SMILES	[nH]1c2c(cc1)cc(nc2)NC(=O)c3ccccc3

Safety Information

WGK Germany	3
HS Code	2933.99.8290
Storage Class	11 - Combustible Solids

Usage And Synthesis

Uses

OAC1 enhances iPSC reprogramming efficiency.

General Description

A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1 μM OAC1 treatment starts 48 h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294 (Cat. No. 382190), Tranylcypromine (Cat. No. 616431), VPA (Cat. No. 676380), and Vitamin C (Cat. No. 1813), in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO (Cat. No. 361550) is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: yes

in vivo

OAC1 (50000 CB CD34⁺ cells with OAC1(500 nM); i.h.; 16 weeks) enhances short and long-term engrafting hematopoietic stem cells (HSC) in irradiated NSG mice^[2].

Animal Model:	Irradiated NSG mice with OAC1 or vehicle control treated CB CD34⁺ cells within 24h after irradiation^[2]
Dosage:	16 weeks
Administration:	Subcutaneous injection OAC1(500 nM) treated CB CD34⁺ cells
Result:	Increased cord blood (CB) cells in primary recipients, compared to the vehicle control group, with the board increase for human B cells, T cells, and myeloid cells in the bone marrow (BM) of primary recipients, resulting in a significant expansion of SRC numbers.

IC 50

TET1

storage

+4°C

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