Peptidyl arginine deiminase has been used in a study that assessed promising novel biomarkers for the early diagnosis of rheumatoid arthritis. It has also been used in a study to investigate the autopathogenic correlation of periodontitis and rheumatoid arthritis.
Peptidyl arginine deiminase is the enzyme that converts arginine into citrulline.
Calcium is required for peptidylarginine deiminase activity in vitro.