Roxatidine acetate hydrochloride is an H2 antagonist, differing considerably in
structure from other marketed agents(cimetidine, ranitidine and famotidine) in this
category. It is useful in the treatment of gastric, duodenal and anastomotic ulcers,
Zollinger-Ellison syndrome and peptic esophagitis.
Roxatidine acetate is a competitive histamine H2 receptor antagonist that upon oral absorption is rapidly converted to its active metabolite roxatidine. By inhibiting the binding of histamine to H2 receptors, roxatidine reduces both intracellular cAMP concentrations and gastric acid secretion by parietal cells.
A histamine H2-receptor antagonist. It is used to inhibit gastric acid secretion; an antiulcer agent.
ChEBI: Roxatidine acetate hydrochloride is a member of piperidines. It contains a Roxane.
