Description
Roxatidine acetate hydrochloride is an H2 antagonist, differing considerably in
structure from other marketed agents(cimetidine, ranitidine and famotidine) in this
category. It is useful in the treatment of gastric, duodenal and anastomotic ulcers,
Zollinger-Ellison syndrome and peptic esophagitis.
Description
Roxatidine acetate is a competitive histamine H
2 receptor antagonist that upon oral absorption is rapidly converted to its active metabolite roxatidine. By inhibiting the binding of histamine to H
2 receptors, roxatidine reduces both intracellular cAMP concentrations and gastric acid secretion by parietal cells.
Chemical Properties
White Solid
Originator
Teikoku Hormone (Japan)
Uses
A histamine H2-receptor antagonist. It is used to inhibit gastric acid secretion; an antiulcer agent.
Definition
ChEBI: Roxatidine acetate hydrochloride is a member of piperidines. It contains a Roxane.
