ChemicalBook > Product Catalog > API > Antiparasitic drugs > Antiamoebic and anti-trichomoniasis drugs > 5,7-Diiodo-8-quinolinol
5,7-Diiodo-8-quinolinol Chemical Properties
- Melting point:>200 °C (dec.)(lit.)
- Boiling point:370.95°C (rough estimate)
- Density 2.3013 (estimate)
- pkapKa 8.0 (Uncertain)
- Merck 14,5042
- CAS DataBase Reference83-73-8(CAS DataBase Reference)
- NIST Chemistry Reference5,7-Diiodo-8-hydroxyquinoline(83-73-8)
- EPA Substance Registry System5,7-Diiodo-8-quinolinol (83-73-8)
5,7-Diiodo-8-quinolinol Usage And Synthesis
- UsesGABA prodrug
- UsesIt acts as an amoebicidal and so used in the treatment of amoebiasis, balantidiasis (an infection caused by protozoa).
- IndicationsIodoquinol (diiodohydroxyquin, Yodoxin, Moebiquin)
is a halogenated 8-hydroxyquinoline derivative whose
precise mechanism of action is not known but is thought
to involve an inactivation of essential parasite enzymes.
Iodoquinol kills the trophozoite forms of E. histolytica,
B. coli, B. hominis, and Dientamoeba fragilis.
Iodoquinol is absorbed from the gastrointestinal tract and is excreted in the urine as glucuronide and sulfate conjugates. Most of an orally administered dose is excreted in the feces. Iodoquinol has a plasma half-life of about 12 hours.
Iodoquinol is the drug of choice in the treatment of asymptomatic amebiasis and D. fragilis infections. It is also used in combination with other drugs in the treatment of other forms of amebiasis and as an alternative to tetracycline in the treatment of balantidiasis.
Adverse reactions are related to the iodine content of the drug; the toxicity is often expressed as skin reactions, thyroid enlargement, and interference with thyroid function studies. Headache and diarrhea also occur. Chronic use of clioquinol, a closely related agent, has been linked to a myelitislike illness and to optic atrophy with permanent loss of vision.
- brand nameQuinadome (Bayer); Yodoxin (Glenwood).
- Clinical Use5,7-Diiodo-8-quinolinol, 5,7-diiodo-8-hydroxyquinoline,or diiodohydroxyquin (Yodoxin, Diodoquin, Diquinol) is ayellowish to tan microcrystalline, light-sensitive substancethat is insoluble in water. It is recommended for acute andchronic intestinal amebiasis but is not effective in extraintestinaldisease. Because a relatively high incidence of topicneuropathy has occurred with its use, iodoquinol should notbe used routinely for traveler’s diarrhea.
- Safety ProfilePoison by ingestion and intravenous routes. Human systemic effects by ingestion: eye effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Iand Nox
- Purification MethodsIt crystallises from xylene and is dried at 70o in a vacuum. [Beilstein 21 II 58.]
5,7-Diiodo-8-quinolinol Preparation Products And Raw materials
- Raw materials8-Hydroxyquinoline
- Company Name:Changzhou Luowan Biological Technology Co., Ltd. Gold
- Company Name:Shanghai Boyle Chemical Co., Ltd.
- Tel:Mr Qiu:021-50182298(Demestic market) Miss Xu：021-50180596（Abroad market）
- Company Name:J & K SCIENTIFIC LTD.
- Tel:400-666-7788 010-82848833-
- Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel:400-660-8290 21-61259100-
- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:18930552037 821-50328103-801