White needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the fruit of Psoralea corylifolia.
Neobavaisoflavone is a DNA polymerase inhibitor and platelet aggregation inhibitor.
ChEBI: Neobavaisoflavone is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with an additonal hydroxy group at position 4' and a prenyl group at position 3'. Isolated from seeds of Psoralea corylifolia, it exhibits inhibitory activity against DNA polymerase and platelet aggregation. It has a role as a platelet aggregation inhibitor, an antineoplastic agent, a plant metabolite and an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor.
Neobavaisoflavone (30 mg/kg; i.p. for 6 weeks) inhibits osteoclastogenesis, promotes osteogenesis and ameliorates bone loss in ovariectomized mice[3].
| Animal Model: | C57BL/6 female mice (8 weeksd; 20-25 g) were removed bilateral ovaries[3] |
| Dosage: | 30 mg/kg |
| Administration: | I.p. for 6 weeks |
| Result: | Attenuated bone loss by inhibiting osteoclast activation and promoting osteogenesis in ovariectomized mice. |
