(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE

clear colorless to yellow liquid

(S)-(+)-2-(Methoxymethyl)pyrrolidine may be used to prepare planar chiral 2-phospha[3]ferrocenophanes. It may also be used as an organocatalyst in the cross-aldol reaction of dihydroxyacetone with p-nitrobenzaldehyde to form the corresponding polyol. SMP reacts with benzoylformic acid to form (S)-N-benzoylformyl-2-(methoxymethyl)-pyrrolidine.

ChEBI: (S)-2-(methoxymethyl)pyrrolidine is a member of the class of pyrrolidines in which the only substituent is a methoxymethyl group at position 2 (the S-enantiomer0. It is a member of pyrrolidines and an ether.

(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE is used for chiral auxiliary; asymmetric syntheses with SMP enamines and SMP amides; asymmetric Birch reductions; asymmetric Diels-Alder reactions.

(S)-(+)-2-(methoxymethyl)pyrazolidine is an organic intermediate that can be prepared from (S)-proline reduction to prepare (S)-2-hydroxymethylpyrrolidine, then formylated and methylated to prepare (S)-(-)-2-(methoxymethyl)-1-pyrrolidinecarboxaldehyde, and finally deformylated to obtain (S)-(+)-2-(methoxymethyl)pyrazolidine.

(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE stores at 0-4 °C under an argon atmosphere.