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DIHYDROERGOTAMINE MESYLATE

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DIHYDROERGOTAMINE MESYLATE Basic information
DIHYDROERGOTAMINE MESYLATE Chemical Properties
  • solubility methanol: 21 mg/mL
  • form powder
  • color white
Safety Information
  • Hazard Codes Xn
  • Risk Statements 20/21/22
  • Safety Statements 36
  • WGK Germany 3
  • RTECS KE7920000
MSDS
DIHYDROERGOTAMINE MESYLATE Usage And Synthesis
  • OriginatorRedergin,Lek
  • UsesCognition adjuvant.
  • Manufacturing ProcessDihydrotoxine is a mixture of three hydrogenated alkaloides of ergot spur. (Claviceps purpurea). 10 g ergotoxine (the mixture of ergocornine, ergocristine, ergocryptine 1:1:1) in 200 ml dioxane and 20 g Pd/BaSO4 were stirred at a H2 pressure 10 atmospheres at 80°C for 5 hours. The catalyst was filtered off, a filtrate was distilled to dryness in vacuum. The residue was in chloroform dissolved and shook with aluminum oxide. The Al2O3 was filtered off, the filtrate was crystallized after adding of hot benzene and cooling. Yield 6-8 g dihydroergotoxine. It crystallized with 1 mol of benzene. MP: 185°C.
  • brand nameAlkergot (Sandoz); Circanol(3M Pharmaceuticals); Deapril (Bristol-Myers Squibb);Gerimal (Watson); Hydergine (Novartis).
  • Therapeutic FunctionVasodilator
DIHYDROERGOTAMINE MESYLATE(11032-41-0)Related Product Information
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