奈西利肽
奈西利肽 性质
密度 | 1.52±0.1 g/cm3(Predicted) |
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RTECS号 | EE1534000 |
储存条件 | −20°C |
形态 | 粉末 |
颜色 | 白色至米白色 |
水溶解性 | Soluble in water at 1mg/ml |
序列 | H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH(Disulfide bridge: Cys10-Cys26) |
CAS 数据库 | 124584-08-3 |
奈西利肽 用途与合成方法
[2]刘翀. 奈西利肽:安全有效的治疗急性失代偿性心力衰竭新药[A]. 浙江省医学会心血管病学分会.2004年浙江省心血管病学学术年会论文汇编[C].浙江省医学会心血管病学分会:,2004:1.
[3]傅毅.重组人B型利钠肽类心衰治疗药奈西利肽(nesiritide)[J].国外医药(合成药生化药 制剂分册),2002(04):251-252. Nesiritide (Brain Natriuretic Peptide-32 human) 是纳利尿肽受体 (NPRs) 的激动剂,其对 NPR-A 和 NPR-C 的 Kd 值分别为 7.3,13 pM。
Kd: 7.3 Pm (NPR-A), 13 pM (NPR-C).
Nesiritide (Brain Natriuretic Peptide-32 human) is an agonist of natriuretic peptide receptor (NPR) , with K d values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. ProBNP1-108 stimulates guanylyl cyclase-A (GC-A) to near-maximum activities but is 13-fold less potent than Nesiritide (BNP1-32). ProBNP1-108 binds human GC-A 35-fold less tightly than Nesiritide. Neither proBNP1–108 nor Nesiritide activates GC-B. The natriuretic peptide clearance receptor binds proBNP1-108 3-fold less tightly than Nesiritide. The half time for degradation of proBNP1-108 by human kidney membranes is 2.7-fold longer than for Nesiritide, and the time required for complete degradation is 6-fold longer. Nesiritide and proBNP1-108 are best fitted by first- and second-order exponential decay models, respectively.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
奈西利肽 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024-11-08 | HY-P0003 | 奈西利肽 | 124584-08-3 | 1mg | 2800 |
2024-08-19 | HY-P0003 | 奈西利肽 | 124584-08-3 | 5mg | 8400 |