Ryania insecticide is the ground stem wood of the
tropical tree Ryania speciosa Vahl., and it contains over a
dozen of several structurally related alkaloids. Nowadays,
this botanical preparation is of minor importance, but
one of its major ingredients, ryanodine, is a widely used
pharmacological tool in studies of the calcium release
channels in sarcoplasmic reticulum membranes of skeletal
and cardiac muscle of both insects and mammals (11,12).
Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)
