Propargyl-PEG4-thiol

Product NamePropargyl-PEG4-thiol
CAS1347750-80-4
MFC11H20O4S
MW248.3391
EINECS
MOL File1347750-80-4.mol

Chemical Properties

Boiling point	332.9±37.0 °C(Predicted)
Density	1.064±0.06 g/cm3(Predicted)
solubility	Soluble in DMSO, DCM, DMF
pka	9+-.0.10(Predicted)

Usage And Synthesis

Description

Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.

Biological Activity

Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

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PEGs