Propargyl-PEG10-acid

Product NamePropargyl-PEG10-acid
CAS2055022-18-7
MFC24H44O12
MW524.6
EINECS
MOL File2055022-18-7.mol

Chemical Properties

Boiling point	593.9±50.0 °C(Predicted)
Density	1.124±0.06 g/cm3(Predicted)
storage temp.	Store at Room Tem.
solubility	Soluble in Water, DMSO, DCM, DMF
pka	4.28±0.10(Predicted)
form	Liquid (Density: 1.124±0.06 g/cm3)
color	Colorless to light yellow

Usage And Synthesis

Description

Propargyl-PEG10-acid is a propargyl PEG linker with a terminal carboxylic acid. The terminal carboxylic acid forms amide bonds with primary amines; activators (EDC or HATU) will be needed. The propargyl group can react with azide-bearing compounds to form stable triazole bonds.

Uses

Propargyl-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG10-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005