Propargyl-PEG10-t-butyl ester

Product NamePropargyl-PEG10-t-butyl ester
CAS2055022-22-3
MFC28H52O12
MW580.71
EINECS
MOL File2055022-22-3.mol

Chemical Properties

Boiling point	592.3±45.0 °C(Predicted)
Density	1.072±0.06 g/cm3(Predicted)
solubility	Soluble in Water, DMSO, DCM, DMF

Usage And Synthesis

Description

Propargyl-PEG10-t-butyl ester is a crosslinking reagent that can react with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The carboxyl group can be deprotected under acidic conditions.

Uses

Propargyl-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG10-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005