Propargyl-PEG4-thiol
- Product NamePropargyl-PEG4-thiol
- CAS1347750-80-4
- CBNumberCB13155016
- MFC11H20O4S
- MW248.3391
- MDL NumberMFCD29764343
- MOL File1347750-80-4.mol
Chemical Properties
| Boiling point | 332.9±37.0 °C(Predicted) |
| Density | 1.064±0.06 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DCM, DMF |
| pka | 9?+-.0.10(Predicted) |
Propargyl-PEG4-thiol Chemical Properties,Usage,Production
Description
Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.Biological Activity
Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs).in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Non-cleavable < span> | PEGs
|
Preparation Products And Raw materials
Propargyl-PEG4-thiol Supplier
Global(40)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 | |
| +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 | |
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contact@trustwe.com | China | 5738 | 58 | |
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| +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 | |
| 021-61551611 13296011611 |
contact@trustwe.com | China | 9900 | 58 |
1347750-80-4, Propargyl-PEG4-thiolRelated Search
- HS-PEG4-CH2CH2COOH
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- Acetylene-PEG5-acid
- Propargyl-PEG8-acid
- Aminooxy-PEG4-Propargyl
- Propargyl-PEG3-Bromide
- Aminoxy-PEG3-Propargyl
- Propargyl-PEG7-acid
- Aminooxy-PEG1-propargyl
- Propargyl-PEG4-bromide
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