Description
Propargyl-PEG5-acid has a propargyl group at one end and an acid group at the other end. The acid can react with primary amines to form a stable amide bond, activation will be needed. The PEG units enhances solubility of the molecule in aqueous environment. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.
Uses
Alkyne-PEG5-acid may be used in the synthesis of peptide nucleic acid (PNA) oligomers that can conjugate with vitamin B
12 via Cu-catalyzed 1,3-dipolar cycloaddition in order to study if vitamin B
12 to transport PNA oligonucleotides into bacterial cells.
