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ELASTATINAL

Product NameELASTATINAL
CAS51798-45-9
MFC21H36N8O7
MW512.56
EINECS257-426-7
MOL File51798-45-9.mol

Chemical Properties

storage temp.	-20°C
solubility	H₂O: 20 mg/mL, clear, yellow
form	Yellow solid.
color	off-white
biological source	microbial
Water Solubility	water: 20mg/mL, clear, faintly yellow to yellow
BRN	873543
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChIKey	IJWCGVPEDDQUDE-YGJAXBLXSA-N
SMILES	[H]C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)N[C@@H](CC(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1

Safety Information

Safety Statements	22-24/25
WGK Germany	3
RTECS	LZ9600000
F	10
Storage Class	11 - Combustible Solids

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Description

Elastatinal is a potent inhibitor of pancreatic elastase (K_i = 240 nM) that is produced by various species of Actinomycetes. It more strongly inhibits pancreatic elastase versus the leukocyte-derived enzyme. Elastatinal reduces electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, indicating substrate recognition by 2A proteinases is similar to that of pancreatic elastases. It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands.

Uses

Elastatinal is an elastase inhibitor.

Biochem/physiol Actions

Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

References

[1] H UMEZAWA. Letter: Elastatinal, a new elastase inhibitor produced by actinomycetes.[J]. Journal of Antibiotics, 1973, 26 12: 787-789. DOI:10.7164/antibiotics.26.787
[2] KAZUYUKI NAKAJIMA. Identification of Elastase as a Secretory Protease from Cultured Rat Microglia[J]. Journal of Neurochemistry, 1992, 58 4: 1401-1408. DOI:10.1111/j.1471-4159.1992.tb11356.x
[3] A MOLLA E W C U Hellen. Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors.[J]. Journal of Virology, 1993, 67 8: 4688-4695. DOI:10.1128/jvi.67.8.4688-4695.1993
[4] L. MENÉNDEZ-ARIAS S O C Risco. Isolation and characterization of alpha 2-macroglobulin-protease complexes from purified mouse mammary tumor virus and culture supernatants from virus-infected cell lines.[J]. The Journal of Biological Chemistry, 1992, 9 1: 11392-11398. DOI:10.1016/s0021-9258(19)49923-7

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