3,5-Dichloro-4-fluorobenzotrifluoride

CLEAR LIGHT YELLOW LIQUID

3,5-Dichloro-4-fluorobenzotrifluoride may be used for the synthesis of 3-[4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]]-3-(trifluoromethyl)diazirine.

3,5-Dichloro-4-fluorobenzotrifluoride is an aryl fluorinated building block.

In a 1L three-necked reaction flask equipped with a stirrer, reflux condenser and temperature ground, 200 g of 3,4,5-trichlorobenzotrifluoride and 200 g of potassium fluoride and 500 ml of cyclobutanesulfone were added, then heated to 190??C, kept warm and stirred for 20 hours and then cooled down to 100??C. 200 g of the crude product (containing about 10% of the cyclobutanesulfone) was evaporated under 0.01 MPa pressure. Then the temperature was raised to 150 ?? and the pressure was reduced to recover the cyclobutanesulfone (can be directly used in the next batch of reaction). 200 g of crude 3,5-dichloro-4-fluorobenzotrifluoride was directly used in the next step of the ammoniation reaction.