(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one

Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities. It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml. It also reverses increases in protein levels of phosphatase 2A (PP2A) and α-synuclein and reverses decreases in the phosphorylated forms of PP2A and α-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC₅₀ = 54.17 μM) but not non-cancerous human CCD-18Co colon cells (IC₅₀ = 109.11 μM).

A slightly yellow oily substance, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Chuanxiong.

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one has anti-cerebral ischemia and anti-Alzheimer's disease effects, and can inhibit uterine rhythmic contractions.

ChEBI: Senkyunolide is a member of 2-benzofurans.

[1] LEONARD F. BJELDANES  In S K. Phthalide components of celery essential oil[J]. The Journal of Organic Chemistry, 1977, 42 13: 2333-2335. DOI: 10.1021/jo00433a033
[2] SHENGLAN GONG. Senkyunolide A protects corticosterone-induced cell apoptosis via modulating protein phosphatase 2A and α-synuclein[J]. bioRxiv: the preprint server for biology, 2017, 24 1. DOI: 10.1101/145326
[3] WINNIE LAI TING KAN. Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells[J]. Journal of ethnopharmacology, 2008, 120 1: Pages 36-43. DOI: 10.1016/j.jep.2008.07.027