Basic information Description References Safety Related Supplier
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Basic information Description References Safety Related Supplier
MONOCROTALINE Basic information
MONOCROTALINE Chemical Properties
  • Melting point:204 °C (dec.)(lit.)
  • alpha -54.8o (C=5 IN CHLOROFORM)
  • Boiling point:463.55°C (rough estimate)
  • Density 1.1512 (rough estimate)
  • refractive index 1.5500 (estimate)
  • storage temp. 2-8°C
  • pka12.21±0.60(Predicted)
  • form neat
  • Water Solubility 11.86g/L(temperature not stated)
  • Merck 13,6274
  • BRN 48732
  • IARC2B (Vol. 10, Sup 7) 1987
  • EPA Substance Registry SystemMonocrotaline (315-22-0)
Safety Information
  • Hazard Codes T
  • Risk Statements 25-40-35
  • Safety Statements 36/37/39-45
  • RIDADR UN 1544 6.1/PG 3
  • WGK Germany 3
  • RTECS QB3140000
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29399990
  • ToxicityLD50 orally in rats: 71 mg/kg (Newberne)
MONOCROTALINE Usage And Synthesis
  • DescriptionMonocrotaline (MCT) is a toxic 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria spectabilis plant. It poisons livestock and humans through the ingestion of contaminated grains and other foods. Pyrrolizidine alkaloid is activated by cytochrome P450 to the reactive pyrrole metabolite dehydromonocrotaline (MCTP) in the liver. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature.
    Monocrotaline is produced for research use. It is used in rat model to investigate human pulmonary hypertension as it offers technical simplicity, reproducibility, and low cost compared with other models of pulmonary hypertension.
  • References[1] Jose G. Gomez-Arroyo, Laszlo Farkas, Aysar A. Alhussaini, Daniela Farkas, Donatas Kraskauskas, Norbert F. Voelkel, Harm J. Bogaard (2012) The monocrotaline model of pulmonary hypertension in perspective, Am J Physio Lung Cell Mol Phyisol, 302, L363-L369
  • Chemical PropertiesWhite to light tan powder
  • UsesA toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
  • Usesantineoplastic, insect sterilant
  • Safety ProfileSuspected carcinogen with experimental carcinogenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Purification MethodsCrotaline forms prisms from absolute EtOH and recrystallises also from CHCl3. UV in 96% EtOH has max 217nm (log  3.32). [Adams et al. J Am Chem Soc 74 5612 1952, Culvenor & Smith Aust J Chem 10 474 1957.] The hydrochloride has m 212-214o (from MeOH/Et2O) and [] D28 -38.4o (c 5, H2O) [Adams & Gianturco J Am Chem Soc 78 1922 1956]. The picrate has m 230-231.5o(dec) [Adams et al. J Am Chem Soc 74 5614 1952]. [Beilstein 27 III/IV 6660.]
MONOCROTALINE(315-22-0)Related Product Information
  • Company Name:Chengdu Biopurify Phytochemicals Ltd. Gold
  • Tel:18080487181 028-82633397
  • Products Intro:Product Name:Monocrotaline
    Purity:>95%,98%,99% by HPLC-UV or HPLC-ELSD Package:From mgs to grams, According to customer request. Inquire for Bulk scale.
  • Company Name:Sichuan Kaike Pharmaceutical Technology Co., Ltd Gold
  • Tel:13981731671
  • Products Intro:Product Name:Monocrotaline
    Purity:98% HPLC Package:500G, 100G, 10G
  • Company Name:Chengdu Peter-like Biotechnology Co., Ltd. Gold
  • Tel:18108052721 028-81700200-
  • Products Intro:Product Name:Crotaline
    Purity:HPLC>=98% Package:5mg;10mg;20mg;50mg;100mg;200mg;500mg;1g
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Products Intro:Product Name:Crotaline, 98%, from Lilium brownii F.E.Br. ex Miellez
    Purity:98% Package:10MG
  • Company Name:Chembest Research Laboratories Limited
  • Tel:021-20908456-
  • Products Intro:Product Name:Monocrotaline(Crotaline)
    Purity:98% Package:10g Remarks:C11518