Dodecyl gallate

This gallate ester (E 310) is an antioxidant added to foods and cosmetics to prevent oxidation of unsaturated fatty acids. Cases have been reported in workers in the food industry, gallate being contained in margarine. It is also present in washing powder.

white to cream powder

Dodecyl 3,4,5-Trihydroxybenzoate is used in method for stabilizing the pH of an aqueous compound comprising drug.

Dodecyl gallate is an antioxidant in cosmetic and pharmaceutical creams and emulsions, various fats, oils, waxes, and foods, such as margarine.

Dodecyl Gallate is an antioxidant used in cream cheese, instant mashed potatoes, margarine, fats, and oils.

ChEBI: Dodecyl gallate is a gallate ester.

Lauryl gallate is a major monomer flavanol found in green tea and shows antioxidant activity in polymers.

Dodecyl gallate exhibits both potent chain-breaking and preventive antioxidant activity. The pyrogallol moiety is responsible for both activities. Dodecyl (lauryl) gallate prevents generation of superoxide radicals by xanthine oxidase, and this activity comes from its ability to inhibit the enzyme^[1].

This gallic acid ester (E 310) is an antioxidant added to food and cosmetics to prevent oxidation of unsaturated fatty acids. Cases were reported in workers of the food industry, gallate being contained in margarine, and from washing powder.

Poison by ingestion and inhalation. Moderately toxic by skin contact. A severe eye irritant. Questionable carcinogen with experimental tumorigenic data. A pesticide. When heated to decomposition it emits very toxic fumes of NOx.

In a 2-year feeding study, with the administration of up to 5 mg/kg of feed to rats, no increase in tumor incidence was noted . In female mice, a dermal injection of dodecyl gallate (100 nmol in 0.2mL acetone) inhibits the formation of skin carcinomas and papillomas induced by the tumor promoter phorbol myristate and the initiator 7,12-dimethylbenz[a]anthracene .

[1] Kubo, I., Masuoka, N., Xiao, P., Haraguchi, H. (2002). Antioxidant Activity of Dodecyl Gallate. Journal of Agricultural and Food Chemistry, 50 12, 3533–3539. https://doi.org/10.1021/jf011250h