White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Desmodium sibiricum.
Vicenin 2 (CAS# 23666-13-9) is a biologically active compound extracted from Hypericum salsugineum and displays significant anti-cancer effects on breast carcinoma cell lines.
ChEBI: Isovitexin 8-C-beta-glucoside is a C-glycosyl compound that is isovitexin in which the hydrogen at position 8 is replaced by a beta-D-glucosyl residue. It has a role as a metabolite. It is a trihydroxyflavone and a C-glycosyl compound. It is functionally related to an isovitexin.
A method for simultaneous isolation of schaftoside, vicenin-2, and ecdysterone from Sagina japonica:
1. Ethanol extraction, followed by solvent partitioning to obtain an n-butanol extract.
2. The extract is fractionated on an AB-8 macroporous resin column, eluting with 50% ethanol to enrich the target compounds.
3. The enriched fraction is separated on an ODS reversed-phase column, yielding three preliminary fractions.
4. Impure vicenin-2 and schaftoside are further purified separately on silica gel columns.
Vicenin 2 (50 mg/kg; orally administration; for 7 days) effectively reduces the MPO activity, attenuates the expression of pro-inflammatory cytokines and key inflammatory markers, in DSS-induced colitis mice[3].
| Animal Model: | Male C57BL/6J mice (25 g) treated with Dextran sulfate sodium (DSS)[3] |
| Dosage: | 50 mg/kg |
| Administration: | Orally administration; for 7 days |
| Result: | Effectively suppressed DSS-induced colitis by attenuating expressions of key inflammatory mediators. |
